Folate (categories 2)
Folate range (<40 vs >=40)
Global tests
Type III ANOVA on main and interaction effects, and LM model summaries.
PRL (ng/ml)
|
|
Chisq
|
Df
|
Pr(>Chisq)
|
|
|
(Intercept)
|
135.6600587
|
1
|
<0.0001
|
***
|
|
Folate_gp2
|
4.6986120
|
1
|
0.03
|
*
|
|
Study
|
0.0222185
|
1
|
0.9
|
ns
|
|
GA_samp
|
126.0704095
|
1
|
<0.0001
|
***
|
|
Folate_gp2:Study
|
0.5210428
|
1
|
0.5
|
ns
|
hPL (μg/ml)
|
|
Chisq
|
Df
|
Pr(>Chisq)
|
|
|
(Intercept)
|
31.5757792
|
1
|
<0.0001
|
***
|
|
Folate_gp2
|
0.5739028
|
1
|
0.4
|
ns
|
|
Study
|
16.4561933
|
1
|
<0.0001
|
***
|
|
GA_samp
|
1623.7970207
|
1
|
<0.0001
|
***
|
|
Folate_gp2:Study
|
2.4557886
|
1
|
0.1
|
ns
|
GH2 (ng/ml)
|
|
Chisq
|
Df
|
Pr(>Chisq)
|
|
|
(Intercept)
|
326.5768112
|
1
|
<0.0001
|
***
|
|
Folate_gp2
|
0.2185473
|
1
|
0.6
|
ns
|
|
Study
|
0.6228831
|
1
|
0.4
|
ns
|
|
GA_samp
|
799.2090412
|
1
|
<0.0001
|
***
|
|
Folate_gp2:Study
|
0.2208327
|
1
|
0.6
|
ns
|
Insulin (uU/ml)
|
|
model term
|
df1
|
df2
|
F.ratio
|
Chisq
|
p.value
|
|
|
1
|
Folate_gp2
|
1
|
Inf
|
1.138
|
1.138
|
0.3
|
ns
|
|
3
|
Study
|
1
|
Inf
|
12.831
|
12.831
|
0.0003
|
***
|
|
4
|
GA_samp
|
1
|
Inf
|
0.112
|
0.112
|
0.7
|
ns
|
|
2
|
Folate_gp2:Study
|
1
|
Inf
|
0.296
|
0.296
|
0.6
|
ns
|
HOMA-IR
|
|
model term
|
df1
|
df2
|
F.ratio
|
Chisq
|
p.value
|
|
|
1
|
Folate_gp2
|
1
|
Inf
|
0.719
|
0.719
|
0.4
|
ns
|
|
3
|
Study
|
1
|
Inf
|
23.967
|
23.967
|
<0.0001
|
***
|
|
4
|
GA_samp
|
1
|
Inf
|
0.182
|
0.182
|
0.7
|
ns
|
|
2
|
Folate_gp2:Study
|
1
|
Inf
|
0.544
|
0.544
|
0.5
|
ns
|
Glucose (mmol/L)
|
|
model term
|
df1
|
df2
|
F.ratio
|
Chisq
|
p.value
|
|
|
1
|
Folate_gp2
|
1
|
Inf
|
0.835
|
0.835
|
0.4
|
ns
|
|
3
|
Study
|
1
|
Inf
|
64.705
|
64.705
|
<0.0001
|
***
|
|
4
|
GA_samp
|
1
|
Inf
|
0.018
|
0.018
|
0.9
|
ns
|
|
2
|
Folate_gp2:Study
|
1
|
Inf
|
3.903
|
3.903
|
0.05
|
ns
|
Model summary
Ratio of Geometric means (95% CI)
PRL (ng/ml)
|
Var
|
Effect
|
P
|
|
(Intercept)
|
13.72 (8.83, 21.34)
|
<0.0001
|
|
Folate_gp2≥40
|
0.91 (0.84, 0.98)
|
0.01
|
|
StudySTOP
|
1.01 (0.89, 1.16)
|
0.85
|
|
GA_samp
|
1.16 (1.13, 1.20)
|
<0.0001
|
hPL (μg/ml)
|
Var
|
Effect
|
P
|
|
(Intercept)
|
1.94 (1.55, 2.43)
|
<0.0001
|
|
Folate_gp2≥40
|
0.99 (0.95, 1.03)
|
0.48
|
|
StudySTOP
|
1.14 (1.07, 1.23)
|
0.0002
|
|
GA_samp
|
1.34 (1.32, 1.36)
|
<0.0001
|
GH2 (ng/ml)
|
Var
|
Effect
|
P
|
|
(Intercept)
|
0.06 (0.05, 0.08)
|
<0.0001
|
|
Folate_gp2≥40
|
0.96 (0.91, 1.02)
|
0.20
|
|
StudySTOP
|
1.03 (0.94, 1.13)
|
0.52
|
|
GA_samp
|
1.32 (1.29, 1.34)
|
<0.0001
|
Insulin (uU/ml)
|
Var
|
Effect
|
P
|
|
(Intercept)
|
16.05 (9.10, 28.32)
|
<0.0001
|
|
Folate_gp2≥40
|
0.95 (0.85, 1.05)
|
0.31
|
|
StudySTOP
|
0.71 (0.60, 0.86)
|
0.0003
|
|
GA_samp
|
0.99 (0.96, 1.03)
|
0.73
|
HOMA-IR
|
Var
|
Effect
|
P
|
|
(Intercept)
|
3.96 (2.19, 7.18)
|
<0.0001
|
|
Folate_gp2≥40
|
0.96 (0.86, 1.07)
|
0.45
|
|
StudySTOP
|
0.62 (0.51, 0.75)
|
<0.0001
|
|
GA_samp
|
0.99 (0.96, 1.03)
|
0.66
|
Glucose (mmol/L)
|
Var
|
Effect
|
P
|
|
(Intercept)
|
5.47 (4.92, 6.07)
|
<0.0001
|
|
Folate_gp2≥40
|
0.99 (0.95, 1.02)
|
0.49
|
|
StudySTOP
|
0.85 (0.82, 0.89)
|
<0.0001
|
|
GA_samp
|
1.00 (0.99, 1.01)
|
0.89
|
|
Folate_gp2≥40:StudySTOP
|
1.05 (1.00, 1.10)
|
0.05
|
Estimated means
Estimated marginal means (or adjusted means) adjusted for GA at sampling.
PRL (ng/ml)
|
Study
|
response
|
SE
|
df
|
lower.CL
|
upper.CL
|
|
SCOPE
|
95.81370
|
7.927343
|
101.43210
|
81.31139
|
112.9026
|
|
STOP
|
97.08491
|
7.518415
|
78.25765
|
83.21432
|
113.2675
|
hPL (μg/ml)
|
Study
|
response
|
SE
|
df
|
lower.CL
|
upper.CL
|
|
SCOPE
|
89.70208
|
2.651369
|
183.1901
|
84.62054
|
95.08877
|
|
STOP
|
102.61293
|
2.682940
|
112.2757
|
97.43251
|
108.06878
|
GH2 (ng/ml)
|
Study
|
response
|
SE
|
df
|
lower.CL
|
upper.CL
|
|
SCOPE
|
2.270916
|
0.0754325
|
410.8656
|
2.127372
|
2.424146
|
|
STOP
|
2.341951
|
0.0631302
|
207.2018
|
2.220741
|
2.469778
|
Insulin (uU/ml)
|
Study
|
response
|
SE
|
df
|
asymp.LCL
|
asymp.UCL
|
|
SCOPE
|
14.38027
|
0.9045247
|
Inf
|
12.712357
|
16.26702
|
|
STOP
|
10.27784
|
0.4593539
|
Inf
|
9.415826
|
11.21876
|
HOMA-IR
|
Study
|
response
|
SE
|
df
|
asymp.LCL
|
asymp.UCL
|
|
SCOPE
|
3.476492
|
0.2316803
|
Inf
|
3.050812
|
3.961566
|
|
STOP
|
2.146191
|
0.1003656
|
Inf
|
1.958223
|
2.352201
|
Glucose (mmol/L)
|
Study
|
response
|
SE
|
df
|
asymp.LCL
|
asymp.UCL
|
|
SCOPE
|
5.397599
|
0.0657130
|
Inf
|
5.270328
|
5.527943
|
|
STOP
|
4.720152
|
0.0407045
|
Inf
|
4.641043
|
4.800609
|
Comparisons (Overall)
|
Hormone
|
Contrast
|
Ratio of Geometric means (95% CI)
|
P-value
|
|
PRL (ng/ml)
|
≥40 / <40
|
0.91 (0.84, 0.98)
|
0.01
|
|
hPL (μg/ml)
|
≥40 / <40
|
0.99 (0.95, 1.03)
|
0.5
|
|
GH2 (ng/ml)
|
≥40 / <40
|
0.96 (0.91, 1.02)
|
0.2
|
|
Insulin (uU/ml)
|
≥40 / <40
|
0.95 (0.85, 1.05)
|
0.3
|
|
HOMA-IR
|
≥40 / <40
|
0.96 (0.86, 1.07)
|
0.5
|
|
Glucose (mmol/L)
|
≥40 / <40
|
1.01 (0.99, 1.04)
|
0.4
|
Diagnostics
Model diagnositcs.
Diagnositcs for PRL (ng/ml)

Diagnositcs for hPL (μg/ml)

Diagnositcs for GH2 (ng/ml)

Diagnositcs for Insulin (uU/ml)

Diagnositcs for HOMA-IR

Diagnositcs for Glucose (mmol/L)
